Wah Academia Journal of Health and Nutrition
Wah Academia Journal of Health and Nutrition (WAJHN) is a premier, peer-reviewed publication dedicated to advancing research and knowledge in health, nutrition, and related sciences. As part of the prestigious Wah Academia Journal family, WAJHN serves as a platform for academics, researchers, and practitioners to share cutting-edge insights, foster interdisciplinary collaboration, and drive innovation in the global health landscape. At WAJHN, we are committed to: Publishing high-quality, evidence-based research articles, reviews, and case studies. Promoting understanding of health and nutrition challenges through rigorous scientific discourse. Empowering the scientific community by bridging gaps between theory, research, and practice. Our mission is to contribute to healthier societies by disseminating impactful research that informs policy, improves healthcare delivery, and enhances nutritional practices worldwide. Join us in shaping the future of health and nutrition.
Copyright and Licensing Publication is open access Creative Commons Attribution License - CC BY- 4.0 Copyrights: The author retains unrestricted copyrights and publishing rights
Navigating the Intersection of Mental Health and Nutrition in Adolescent Girls: Addressing the Dual Challenge – A short Review
Adolescent girls are especially vulnerable to the twin threats of nutritional inadequacy and mental illness, an interactive effect that has long-term consequences for physical and psychological development. Nutrient deficiencies, particularly in iron, zinc, vitamin D, and common B-vitamins, not only impact growth and immune functioning but also compromise susceptibility to mood disorders, anxiety, depression, and cognitive impairment. Simultaneously, mental health conditions influence feeding patterns, e.g., inadequate nutrient consumption, infrequent or irregular meal frequency, or food restriction and disordered eating, which contribute additional nutrient deficiencies, perpetuating a vicious risk cycle. This review critically examines the complex interaction between nutrition and mental health in adolescent girls, the physiological, neurocognitive, and psychosocial mechanisms linking deficits to psychological outcomes. The article also identifies contextual influences like socio-economic status, cultural norms, and environmental stressors that may magnify vulnerability. Comprehensive strategies that integrate special nutrition interventions such as micronutrient supplementation, dietary diversification, and fortified foods with mental health support activities are recommended to develop resilience, improve cognitive capacity, and general wellbeing. By addressing both nutrition and mental health simultaneously, such strategies aim to mitigate long-term developmental, educational, and health consequences and instead promote adolescent girls to attain their optimal growth and psychological well-being at this critical stage of life.
Copyright (c) 2025 Salwa AL Majali, Mahsa Ebadi, Zeliha Selamoglu, Abdol Ghaffar Ebadi, Mehran Moslemi (Author) https://creativecommons.org/licenses/by/4.0
Climate Change, Food Security, and Human Health: A Comprehensive Analysis of Global Problems and Sustainable Nutritional Plans
Climate change is a global phenomenon of widespread significance with far-reaching implications for food security and human health. Climate change—indicated by rising temperatures, shifts in precipitation patterns, and events of extreme weather—is heavily affecting agricultural productivity, availability of nutritious foods, and food system resilience. While simultaneously decreasing staple food nutritional content is matched by an increase in incidents of foodborne disease, it further exacerbates public health issues. This review provides an in-depth review of how climate change impedes food security and impinges upon human health, focusing on the multifaceted ways that climate variables affect nutrition. Focal areas of emphasis include a decline in crop productivity, a reduction in nutrient content of important crops, drought, and an intensified risk of pathogenic invasions of foods. Vulnerable populations including children, pregnant women, refugees, and those in low-income nations face a higher risk of undernutrition, stunting, micronutrient inadequacies, and an emerging dual threat of a potential obese-undernutrition dual burden. To address these challenges, this current review explores innovative and sustainable nutritional solutions. These measures include promoting plant-based diets, biofortification of major crops, reduction of waste, and integration of circular economy philosophy into food production systems. This work further explores the pivotal role of overarching global governance frameworks and policy drives led by international institutions like the WHO, FAO, and UN, while underscoring the role of climate-smart production methods. Future research directions underscore the urgent need for cross-disciplinary collaboration, integration of climate science with nutritional epidemiology, and application of emerging technologies such as AI and precision agriculture to create robust food systems. Finally, this review calls for a unified global effort to ensure food security, reduce health consequences of climate change, and promote sustainable nutrition in all populations, particularly against the growing climate crisis.
Copyright (c) 2025 Abdol Ghaffar Ebadi, Zeliha Selamoglu (Author) https://creativecommons.org/licenses/by/4.0
Engineering Cancer Resistance: A Novel Framework Inspired by Evolutionary Adaptations
Cancer remains a leading cause of mortality worldwide, characterized by cells that exhibit 'monster traits' such as uncontrolled proliferation, invasiveness, resistance to apoptosis, and immune evasion. Traditional therapies often target single hallmarks of cancer, leading to limited success and eventual resistance. This paper proposes a novel, integrative therapeutic framework inspired by evolutionary adaptations in species with remarkable cancer resistance, such as elephants (Loxodonta Africana). Elephants possess enhanced TP53-mediated cancer surveillance and DNA repair mechanisms, which contribute to their extremely low cancer incidence. We hypothesize that by synthetically recapitulating these 'anti-monster' factors—such as augmented p53 activity, enhanced DNA repair, and controlled inflammation—in human cells, we can reprogram malignant phenotypes towards benignity. Our proposed strategy combines synthetic biology, gene therapy (including CRISPR/Cas systems), and multi-targeted pharmacological approaches to simultaneously address multiple cancer hallmarks. By leveraging advanced *in vitro* organoid and *in vivo* models, this research aims to pioneer a new paradigm in oncology that moves beyond cytotoxic elimination towards cellular reprogramming and durable cancer prevention, potentially yielding a significant reduction in lifetime cancer risk.
Copyright (c) 2025 Hafiz Muhammadismail Azher Syed (Author) https://creativecommons.org/licenses/by/4.0
Bioactivity Profile of Datura stramonium L. Seed Extracts: Collagenase and Tyrosinase Inhibition and Antioxidant Activity
Datura stramonium L., a member of the Solanaceae family, contains diverse phytochemicals with potential pharmacological applications, yet its enzyme inhibitory and antioxidant properties remain insufficiently characterized. In this study, ethanol and aqueous extracts of D. stramonium seeds collected from Belmebük village (Amasya, Turkey) were evaluated for collagenase and tyrosinase inhibition, as well as antioxidant capacity. Enzyme inhibition assays conducted at 20 μg/mL revealed that the ethanol extract inhibited collagenase and tyrosinase by 26.8 ± 0.099% and 59.5 ± 0.025%, respectively, while the aqueous extract showed higher activity with 52.1 ± 0.09% and 70.5 ± 0.012% inhibition. Compared to positive controls (epigallocatechin gallate: 88.09% collagenase inhibition; kojic acid: 98.13% tyrosinase inhibition), the extracts demonstrated moderate but significant activities. Antioxidant evaluations using DPPH and ABTS assays indicated IC₅₀ values of 0.0962 ± 0.0299 and 0.241 ± 0.052 mg/mL for the ethanol extract, and 0.0522 ± 0.0254 and 0.1974 ± 0.0156 mg/mL for the aqueous extract, respectively. Although less potent than standard antioxidants (BHT: 0.0148 ± 0.001 mg/mL; Trolox: 0.0153 ± 0.001 mg/mL), both extracts displayed notable radical scavenging effects, with the aqueous extract consistently outperforming the ethanol extract. These findings highlight that D. stramonium seed extracts possess dual bioactivity by inhibiting collagenase and tyrosinase while exerting antioxidant effects, suggesting their potential in preventing collagen degradation, hyperpigmentation, and oxidative damage. To the best of our knowledge, this is the first report on enzyme inhibitory activities of D. stramonium seed extracts, providing novel evidence for their potential utilization in pharmaceutical and dermocosmetic formulations.
Copyright (c) 2025 Eda SÖNMEZ GÜRER, Fatma Betül SÜREN, Rengin BAYDAR, Ayşe Esra KARADAĞ, Yavuz Bülent KÖSE, Ayhan ALTINTAŞ (Author) https://creativecommons.org/licenses/by/4.0
Antihypertensive Drugs’ Prescribing Pattern in Hypertensive Patients and Adherence with JNC Guidelines
This study aims to investigate the prescribing patterns of antihypertensive drugs among hypertensive patients across different cities and age groups in Pakistan. Hypertension is considered to be a major public health issue, requiring effective management to prevent severe complications like cardiovascular disease and stroke (16). The study attempts to reveals that healthcare providers in Pakistan generally adhere to the established guidelines, such as the JNC 8 recommendations (12), with a particular preference for calcium channel blockers (CCBs) as the initial choice of treatment. This adherence aligns well with the guidelines, which recommend CCBs for certain populations, specifically those at high cardiovascular disease risk. However, the study also uncovers a significant underutilization of thiazide diuretics, despite their strong recommendation as a first-line therapy for hypertension. Thiazide diuretics are well-known for their efficacy, affordability, and endorsement by major guidelines; still they are not being prescribed as frequently as expected. This divergence suggests that there may be some underlying factors influencing prescriber decisions, such as local clinical practices, patient preferences, or concerns about side effects. The findings reveal the need for further investigation into these factors to better understand the reasons behind this underutilization. The research emphasizes the importance of developing personalized treatment plans that not only adhere to the latest evidence-based guidelines but also consider individual patient characteristics and local practices. By addressing these discrepancies in prescribing patterns, healthcare providers can optimize hypertension management, leading to better patient outcomes.
Copyright (c) 2025 Musfera Hashmi, Tahira Mumtaz (Author) https://creativecommons.org/licenses/by/4.0
The Influence of Exercise on Endometriosis Symptoms. Exploring Experiences and Practices among Colombo-Based Members of the Endometriosis Support Group in Sri Lanka
Endometriosis is a chronic and often devastating condition that affects a significant number of women global, triggering symptoms such as heavy menstruation, pelvic pain, and infertility. Even with its recognition by the World Health Organization (WHO) and the designation of March 28 as Endometriosis Awareness Day, there remains no definitive cure or specific medication for the condition. The lack of effective treatment and the severe physical and emotional toll of endometriosis can significantly affect women’s quality of life. Even globally famous Public figures has committed suicide due to unbearable pain and emotions with endometriosis. This study aims to discover the experiences and applies of women with endometriosis in Colombo, Sri Lanka, specifically focusing on the role of general exercise as an empowering tool for handling symptoms and revised overall stranded of living. The study will focus on 70 women who are members of the Endometriosis Support Community Group in Colombo, aged 18 and above. A sample size determination table, a sample size of 59 women will be selected for the research. The main purposes of this study are to examine the effect of general exercise on both physical and mental health, identify the types of exercises trained, and explore how exercise can subsidize to symptom relief. A quantitative approach will be used, with data collected through structured interviews, which will be analyzed using thematic analysis. It is anticipated that the study will reveal that exercise plays a significant role in alleviating physical symptoms, reducing stress, and improving the sense of control over the disorder. The research expected to provide valuable understandings into how exercise can support to women with endometriosis in Sri Lanka, possibly leading to better health outcomes and enhanced stranded of living. This analysis suggests that increased exercise (as an intervention or pain management) is positively associated with symptom reduction. The model showed moderate ability to predict symptoms based on exercise, 46.8%*symptoms (R² = 0.468). The coefficient for exercise is 0.614, suggesting that for every 1-unit increase in exercise, symptom reduction increases by 0.614 units, indicating a positive relationship between the two. As exercise accounts for nearly 47% of the variance in symptoms, combining targeted exercise programs or interventions may improve health outcomes. Additionally, further research may help identify whether increased exercise may lead to better symptom management across different populations in Sri Lanka.
Copyright (c) 2025 D.G U. Gethmini (Author) https://creativecommons.org/licenses/by/4.0
Nutritional profile and Health Benefits of Super Food Ragi (Finger millet): A powerhouse of Calcium
Ragi or Finger millet (Eleusine coracana) is an annually cultivated crop vastly found in the regions of Asia and Africa such as in Ethiopia, India and Srilanka. It ranks as the fourth most produced millet globally. It is densely packed with many nutrients like protein, calcium, iron, and amino acids. It is rich in minerals like phosphorous, calcium and magnesium. Its rich calcium content makes it a powerhouse of Calcium. Ragi can be called as a superfood that conifers valuable health benefits such as enhancing digestion, reducing the risk of heart disease, slowing down aging, regulating diabetes etc. This study highlights the nutritional profile and health benefits of Ragi. Several factors that affect the bioavailability of calcium in ragi have also been discussed. The methods of its consumption and ways to improve the calcium absorbance from Ragi consumption has also been given. Thus, this study affirms that Ragi is a highly recommended crop to provide adequate calcium, especially for low-income groups.
Copyright (c) 2025 Dr. Hajera Sana (Author) https://creativecommons.org/licenses/by/4.0
Integrating Nutrition and Mental Health: Mechanistic Pathways, Clinical Evidence, and Public Health Policy Implications
Mounting evidence reveals a critical intersection of mental health and nutrition, with dietary consumption and nutrient availability influencing cognitive function, mood, and risk for psychiatric illness. This review takes the field a step further by integrating mechanistic pathways, clinical trial data, and public health policy implications into a single framework that differs from earlier reviews. Mechanistically, nutrition affects neuroinflammation, oxidative stress, neurotransmitter synthesis, and the gut–brain axis. Key nutrients—omega-3 fatty acids, B-vitamins, minerals, and polyphenols—sustain neuronal integrity and modulate stress, whereas diets high in processed foods and added sugars make the individual more vulnerable to depression and anxiety. Clinical trials offer proof that dietary quality interventions, specifically Mediterranean-style or nutrient-dense diets, improve mental health outcomes, particularly in vulnerable populations. Importantly, nutrition-based interventions can complement psychiatric treatments and enhance prevention. Policy-level integration, including mental health-specific dietary guidelines and regionally relevant implementation protocols, has the potential to substantially reduce the global disease burden. Research priorities are posited in the form of longitudinal studies, mechanistic trials, and precision nutrition. By establishing nutrition as a preventable risk factor for mental health, this review insists on its inclusion in evidence-based clinical practice and public health policy worldwide.
Copyright (c) 2025 Salwa AL Majali, Mahsa Ebadi, Zeliha Selamoglu, Abdol Ghaffar Ebadi (Author) https://creativecommons.org/licenses/by/4.0
Personalized Nutrition in the Genomics and Digital Age: Current Issues, Future Directions, and Evidence
Personalized nutrition represents a paradigm shift from standard one-size-fits-all dietetic advice to individually tailored intervention based on an individual's genetic profile, metabolic health, lifestyle, and environment. Advances in nutrigenomics and metabolomics have highlighted the role of genetic difference and molecular mechanisms in nutrient metabolism, food response, and disease risk for chronic conditions such as obesity, diabetes, and cardiovascular disease. At the same time, digital health technologies like mobile health applications, wearables, artificial intelligence–driven analytics, and continuous glucose monitoring are enabling real-time data capture and individualized feedback, thereby maximizing compliance and clinical impact of nutrition interventions. This review synthesizes evidence for the convergence of genomics and digital health into personalized nutrition, critically evaluating their common potential for better disease prevention and management. Emerging evidence shows that they can optimize dietary impacts, promote metabolic well-being, and facilitate precision-based preventive therapy but remain problems with respect to interpreting data, validating biomarkers, ethical considerations, access, and cost-effectiveness. By taking into account the current breakthroughs, challenges, and opportunities, this paper advocates for inter-disciplinary action among geneticists, clinicians, nutritionists, and digital health experts, and robust policy regulation to offer secure and equitable embracing of precision nutrition strategies. Future research involves further refining big data integration, optimizing predictive modeling, and translating results to scalable interventions that can be applied in both clinical and public health contexts around the globe, setting personalized nutrition as the basis for next-generation healthcare.
Aynısafa Bitkisi (Calendula officinalis L.) Fitobileşenlerinin Siklooksijenaz-2 Enzimi Üzerine Etkisinin İn Siliko İncelenmesi
Nonsteroidal antiiflamatuvar ilaçlar (NSAİİ), analjezik, antipiretik ve antiinflamatuvar etkiye sahip olup, siklooksijenaz – 2 (COX-2) enzim inhibisyonu yoluyla bu etkileri gösterdikleri belirlenmiştir. Birçok klinik çalışma sonucunda NSAİİ’lerin gastrointestinal ve kardiyovasküler yan etkiler oluşturduğu bulunmuştur. Aynısafa bitksi (Calendula officinalis L.) Asteraceae familyasından bir bitkidir. Bu bitkinin halk tıbbında oldukça sık kullanıldığı ve antitümör, antioksidan, antifungal, antiviral, antiinflamatuvar, antibakteriyel aktiviteler gösterdiği bilinmektedir. Mevcut literatürde Calendula bitkisine ait içerik raporları incelenmiştir (https://phytochem.nal.usda.gov/). Bu çalışma kapsamında moleküler docking çalışması için bitkinin 1,4-Phthalazinedione; Metanephrine bis (trimethylsilyl) ether; Alpha-Cubebene; Beta-Copaene; Nitro-2H-chromene; Beta-Guaiene; Gamma-Muurolene; Isofucosterol, 5-Phytyltoluquınone gibi etken moleküller seçilmiştir. Protein Data Bank (PDB)’den çekilen COX-2 enziminin yapısı moleküler kenetleme (moleküler docking) analizleri ile değerlendirilmiş ve fitokimyasallar ile hedef proteinlerin etkileşimleri belirlenmiştir. Validasyon işlemi için redocking yapılmıştır. PDB (Protein Data Bank) da COX-2 enzimini en iyi temsil edecek şekilde 5KIR yapısı seçilmiştir.
Copyright (c) 2025 Sevgi DURNA DAŞTAN, Şeyda KAYA, Sultan ERKAN, Taner DAŞTAN (Author) https://creativecommons.org/licenses/by/4.0
Evaluating Clinical Outcomes in Pregnant Women with Severe Mental Illness: A Retrospective Audit at University Hospitals Birmingham
Background: Severe mental illness (SMI) is a leading preventable cause of maternal death in the postpartum period with suicide and psychiatric illness contributing to over one third of deaths between 6 weeks and one year postpartum. The interplay of SMI and pregnancy confers complex clinical demands and a high-risk profile, necessitating early detection and risk stratification and a multi-disciplinary management approach. Objective: This aims to assess the clinical profile, therapeutic approaches and maternal/fetal outcomes of pregnant women with SMI clinically managed at University Hospitals Birmingham (UHB) from July 2021 to July 2024, to informance development of care pathways and strategies to improve the uptake of treatment. Methods: A retrospective review was performed using the electronic maternity record system BadgerNet. All pregnant women with SMI who were booked with UHB during the audit timeframe were included. Data collected included demographics, medication status, gestation or referral age to perinatal mental health (PNMH) services, the use of antipsychotics, obstetric monitoring and postnatal outcomes. Qualitative analyses were based on descriptive statistics of the clinical patterns and service gaps. Results: In a cohort of 1,060 pregnant women with a diagnosis of mental illness, 106 (10%) had evidence of SMI. 71 (67%) were receiving antipsychotics prior to pregnancy, whereas 35 (33%) were either medication-naive or data were unavailable. The audit found discrepancies in monitoring rules: ▪ GTT was performed in 100% of the patients on anti-psychotics. ▪ Growth scans were inconsistently performed. ▪ There was suboptimal Lithium and Lamotrigine monitoring: No patient on Lamotrigine had therapeutic levels monitored (0/4). ▪ There were no patients on Sodium Valproate or Lithium at the time of the audit. ▪ FMU referrals and psychiatric evaluations were infrequently noted. Conclusion: Pregnant woman with SMI needs close cross disciplinary care, particularly because of the elevated risks of preterm birth, low birth weight and postnatal relapse. The audit highlights the need for preconception counselling, safe pharmacotherapy, antenatal surveillance and comprehensive postnatal planning. Better compliance to the protocol together with earlier introduction of psychiatric care may result in better maternal and neonatal outcomes.
Copyright (c) 2025 Asia Khan (Author) https://creativecommons.org/licenses/by/4.0
Karnıyarık otunun (Plantago ovata Forsk) Gıda Sektöründe Kullanım Alanları
Karnıyarık otu (Plantago ovata Forsk), dünyanın tropikal bölgelerinde yaygın olarak yetiştirilen, fonksiyonel özellikleriyle öne çıkan tek yıllık bir bitkidir. Ana vatanı, Orta Asya olarak bilinen Karnıyarık otu Hindistan, Pakistan, İran ve Avrupa'da yaygın olarak yetiştirilmektedir. Psyllium cinsinin 200 türü, 56 alt türü bilinmekte olup, Hindistan’da 10, Mısır ve Türkiye’de 21 türü bulunmaktadır. Tohumlarının at kulağına benzetimesi nedeni Hindistan’da isabgol ve ülkemizde tohumun orta kısmındaki karık nedeni ile karnıyarık otu olarak isimlendirilmektedir. Plantoga ovata'nın tohum kabuğu içerdiği çözünür ve çözünmez lifler nedeni ile çeşitli gastrointestinal bozukluklar için terapötik etkinliğini göstermektedir. Ayrıca, Plantago ovata Forsk. antioksidan, immünomodülatör, antiproliferatif, antikanser ve antiviral etkilere sahip olması nedeni ile gıda, tıp ve endüstriyel kullanım alanları da olan bir bitkidir. Bu çalışmada karnıyarık otunun gıda sektöründeki kullanım alanları hakkında bilgiler paylaşılması amaçlanmıştır.
Copyright (c) 2025 Ümmügülsüm ERDOĞAN, Ceyhun TAŞ (Author) https://creativecommons.org/licenses/by/4.0
Beslenme ve Sağlık Ekseninde Doğal Ürünler- “Arı Ürünleri”
Doğal ürünler eskiden beri birçok ülkede tıbbi amaçla özellikle insan hastalıklarının önlenmesinde ve tedavisinde kullanılmaktadır. Son yıllarda doğal antioksidanların insan sağlığı bakımından önemini ortaya koyan çalışmalar yapılmaktadır. Bu amaçla araştırmalar en yararlı bitkileri ve doğal ürünlerin özütlerini tespit etmeye, insan ve çevre sağlığı üzerindeki önemini belirlemeye yoğunlaşmıştır. Dünyanın karşı karşıya kaldığı en önemli problemlerden biri de insanlara yeterli miktarda güvenilir gıda sağlayamamaktır. Günümüzde özellikle gelişmiş ülkelerde toplum bilincinin insan ve çevre sağlığına yoğunlaşması ve doğal ürün kullanımına yönelmesi güvenli gıda üretimini ve sentetik ajanlara alternatif olarak doğal antioksidanların kullanımını önemli kılmıştır. Aynı zamanda tarih boyunca toplumların ekonomik özgürlüğünün bir simgesi olan arıcılık; uygun coğrafi konum, uygun iklim şartları ve zengin bitki örtüsüne sahip ülkelerin sosyo-ekonomik yaşamının vazgeçilmez bir unsuru olmuştur. Bu çalışmada özellikle doğal ürünler arasında hem besin maddesi hem de sağlıklı bir ürün olarak sıkça kullanılan arı ürünleri ve biyolojik potansiyelleri hakkında bilgilere yer verilmiştir.
Copyright (c) 2025 Zeliha Selamoğlu, Elifsena Canan Alp Arıcı (Author) https://creativecommons.org/licenses/by/4.0
Development of Instant Keto Soup Powder by Incorporating Cauliflower for Weight Loss
Cauliflower is a cruciferous vegetable and a significant source of nutrients. Along with disease fighting properties, it has several weight loss friendly qualities. Being a superfood, its low caloric and high fiber content makes it worthy of the title. The aim of this study was to develop an instant keto soup powder incorporated with cauliflower in order to reduce the body weight. The proximate analysis evaluated the Moisture, Fat, Total carbohydrates, Crude protein, Energy, fiber content of the soup powder, likewise, TPC, TFC and DPPH tests analyzed the antioxidants activity of the finalized product. Various compositions T0, T1, T2 and T3 were formulated. The instant powder was obtained after dehydrating cauliflower and combining other essential ingredients that was reconstituted afterwards by boiling water for soup mix preparation. The results indicated that T3 was the most suitable composition. The findings suggested that 40% cauliflower powder is the best composition for instant soup mix.
Copyright (c) 2025 Shanza Mukhtar, Noor Fatima, Areeba Nazir (Author) https://creativecommons.org/licenses/by/4.0
Mantarların Besinsel Gücü: Makro, Mikro Besin Öğeleri ve Fonksiyonel Potansiyelleri Üzerine Kapsamlı Bir Derleme
Mantarlar, düşük kalorili yapılarının yanı sıra zengin besin içerikleriyle dikkat çeken, hem geleneksel hem modern beslenme sistemlerinde giderek daha fazla önem kazanan organizmalardır. Bu derleme çalışmasında, mantar türlerinin makro (protein, karbonhidrat, yağ) ve mikro (vitamin, mineral) besin öğeleri detaylı şekilde değerlendirilmiş; aynı zamanda bu öğelerin insan sağlığına etkileri, biyoaktif rolleri ve fonksiyonel gıda potansiyelleri tartışılmıştır. Özellikle esansiyel amino asit profili dengeli protein içerikleri, bağışıklık sistemi destekleyici beta-glukanlar, kalp sağlığıyla ilişkili doymamış yağ asitleri ve B grubu vitaminler ile D2 vitamini sentez kapasitesi, mantarları besleyici yoğunluğu yüksek ve işlevsel özelliklere sahip gıdalar sınıfına taşımaktadır. Ayrıca selenyum, çinko, demir gibi eser elementlerin varlığı, bu organizmaların bağışıklık ve metabolik sağlık açısından tamamlayıcı bir rol üstlenebileceğini ortaya koymaktadır. Bu bağlamda mantarlar, sürdürülebilir tarım ve sağlıklı beslenme stratejileri açısından gelecekte daha fazla değerlendirilmeye açık, değerli doğal kaynaklardır.
Copyright (c) 2025 Mustafa Sevindik (Author) https://creativecommons.org/licenses/by/4.0
Preeklampsi, gebelik sırasında komplikasyonlara yol açan ve fetal ile maternal morbidite ve mortalitenin en yaygın nedenlerinden biridir. Bu olguda, preeklampsinin gebelik sonuçları üzerindeki etkisini güncel literatür ışığında yorumlamayı amaçladık.
Copyright (c) 2025 Elifsena Canan Alp Arıcı (Author) https://creativecommons.org/licenses/by/4.0
Holistic Approaches to Treating Early Pregnancy Bleeding: Evaluating Medical, Surgical, and Lifestyle Interventions in Diverse Patient Populations with Threatened Miscarriage and Ectopic Pregnancy
Early pregnancy bleeding (EPB) – bleeding within the first trimester – affects roughly 20–30% of pregnancies and is a major source of anxiety for women, with nearly half of affected pregnancies ultimately miscarrying. Common causes include threatened miscarriage and ectopic pregnancy, each requiring distinct management strategies. A holistic approach addressing both clinical and emotional needs is needed. Objective: This study evaluated the effectiveness of a holistic management model for EPB by comparing outcomes of medical, surgical, and lifestyle interventions. Methods: We conducted a retrospective observational cohort study of women (n = 150) presenting with EPB (<14 weeks’ gestation) at a tertiary care center. Patients were managed with progesterone supplementation (for threatened miscarriage), laparoscopic intervention (for ectopic pregnancy), and standardized lifestyle counseling. Primary outcomes included pregnancy continuation, complication rates, and patient-reported anxiety and satisfaction. Data were analyzed using SPSS (independent t-tests, chi-square tests; p < 0.05). Results: Among threatened miscarriage patients, those receiving progesterone (n = 50) had significantly higher rates of ongoing pregnancy (80% vs. 60%, p = 0.01) and reported lower mean anxiety scores (3.2 vs. 5.8, p < 0.001) and greater satisfaction than controls. In the ectopic pregnancy cohort, laparoscopic management (n = 30) resulted in rapid resolution (mean hospital stay ~1.2 days vs. 14.3 days for medical management, p < 0.001) with minimal complications; patient satisfaction was slightly higher in the surgical group. Women who adopted recommended lifestyle modifications reported better emotional outcomes, consistent with existing literature. Conclusions: A multidisciplinary, patient-centered approach to EPB – combining progesterone therapy, timely surgical care, and supportive lifestyle counseling – improves both clinical and psychosocial outcomes. These findings underscore the need for integrated care models that address the full spectrum of patient needs during early pregnancy complications.
Regenerative Medicine and Stem Cell Therapy: Advancements and Future Potential
The stem cell therapy and regenerative medicine sectors are quickly expanding due to the profound impact of stem cells on treating situations that were previously considered untreatable. Regenerative medicine, as a sophisticated field related to cellular biology, tissue engineering, and genetics, leverages the potential of stem cells to heal, regenerate, or restore tissues and organs. In this article, we focus on the latest breakthroughs in pluripotent and mesenchymal stem cells, the development of induced pluripotent stem cells (iPSCs), CRISPR gene editing, and their impact on developing practical solutions for treating neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, and organ failure. The synergistic effects of new biomaterials, 3D bioprinting, and personalized medicine are advancing the precision of therapies. We analyze international clinical trials, ethical debates, policy issues, and the strategic vision concerning the use of advanced regenerative medicine techniques in targeted healthcare. By integrating novel research with anticipated shifts, we aim to equip professionals in stem cell therapy with research-appropriate comprehension and tools.
Copyright (c) 2025 https://creativecommons.org/licenses/by/4.0
Mikro-Besin Selenyum Ve Biyolojik Özellikleri
Uzun yıllar sadece yüksek toksik ve karsinogen özelliğiyle bilinen selenyum, yapılan çalışmalar sonucunda biyolojik sistemler için önemli ve faydalı bir element olarak değerlendirilmiştir. Mikro-besin olan selenyumun, lipit metabolizması sonucu oluşan peroksitlerin yol açtığı oksidatif hasarlardan hücre zarlarının korunmasında etkili olduğu bilinmektedir. Temel eser bir element olan selenyum, immün sistemin normal fonksiyonunda ve antioksidan mekanizmada görev yapan enzimlerin bir parçası olarak, savunma sisteminde yer almaktadır. Yaşamın uzaması ve hastalıkları önlemede, inorganik ve organik selenyum bileşiklerinin gösterdiği kimyasal koruyucu etkilere benzer etkiler gösteren, laboratuvarlarda hayvan çalışmalarında karsinojenezis üzerine çalışılmış önemli sentetik organoselenyum bileşikleri de mevcuttur. Özellikle spesifik organoselenyum bileşiklerinin anti-karsinojen ve anti-oksidatif karaktere sahip olmaları son yıllarda bilim dünyasında son derece ilgi uyandırmıştır.
Preventing Eclampsia: Risk Factors, Early Detection, and Treatment Approaches
Eclampsia is a serious complication and the common cause of death in pregnancy. Eclampsia can be diagnosed on the base of seizures, high blood pressure, proteinuria, headache, visual disturbance, enema and abdominal pain. Some certain factor may increase the chance of eclampsia which include preeclampsia history, first pregnancy, severe hypertension, age obesity and pre-existing conditions. We may not prevent the eclampsia but safety measure can be taken to reduce the risk like prenatal care, managing pre-existing conditions, taking aspirin, maintain healthy weight, managing the stress or balance nutrients. Eclampsia treatment may depend upon seizures and preventing complications for mother and baby which may include anticonvulsant medication, blood pressure control, delivery, supportive care and steroid for fatal lungs development. Goals of this research were to take an overview of the analysis, risk factor, prevention, and treatment of eclampsia and the essential for enhanced care by mother.
Investigating the algae for the synthesis of biofuel by using genetic engineering techniques
Fossil fuels are the main energy source despite they are not producing greenhouse emissions in environment. Research into microalgae genomics resulted in multiple genome sequences where Chlamydomonas reinhardtii received attention because scientists could utilize effective genetic tools. Scientists are developing testing methods for diatoms and industrial algae species but also other significant industrial microorganisms. Scientists worldwide can conduct genetic transformation on all divisional algal species since they successfully adapted more than 30 strains. The insertion of random transgenes through antibiotic markers is possible with nuclear transformation but experts face difficulty in targeted gene deletion due to limited homologous recombination success rates.
Gebelikte Ve Lohusalik Döneminde Beslenme
Dünyaya getirilecek olan yeni bir canlının dünyaya gözünü açmadan önce anne karnında geçirdiği evre dünyaya gözünü açtıktan sonraki hayatı boyunca önemli rol oynamaktadır. Bu kritik sürecin iyi bir şekilde yönetilmesi için gebelik ve lohusalık döneminde kadının beslenmesindeki gereksinimlerin doğru olarak yerine getirilmesi gerekir. Bu makalede gebelik ve lohusalık dönemlerinde gerekli beslenmenin önemi, makro ve mikro besin unsurları, bu dönemdeki beslenmenin çocuk üzerinde etkileri ve beslenme önerileri incelenmiştir.